![]() ![]() ![]() Over the long-term, sleep disorders may compromise recovery and return to meaningful function, representing a potentially treatable contributor to cognitive dysfunction in recovering patients. Untreated sleep disturbances may adversely affect the acute care of AE patients, worsening autonomic instability and challenging attempts to wean patients from mechanical ventilation. Network disruption is also recognized in subtypes of AE, and may contribute to or arise from sleep disturbances in recovering patients. Disease-specific compromise of networks important for sleep initiation and maintenance are presumed to underlie sleep disruption in Alzheimer disease, Parkinson disease, and prionopathies, with the potential that untreated sleep disruption may exacerbate both symptoms and pathological progression of these neurodegenerative diseases. Sleep disturbances are increasingly recognized as common manifestations of neurologic disease. Sleep disturbances in neurological disease and AE However, the types of sleep complaints, association with specific subtypes of AE, and contributions of sleep disturbances to the clinical presentation and long-term outcomes in recovering AE patients remain unknown. Sleep disturbances are now well-recognized in patients with specific subtypes of AE (i.e., AE associated with antibodies against IgLON5 ), and in almost 75% of patients reported in a case series incorporating systematic screening for sleep complaints. Accordingly, reports of sleep disorders in AE patients were initially limited to disparate collections of cases associated with dramatic symptoms. Increased attention has also contributed to a better understanding of the symptoms, signs, and comorbidities common in AE patients-including sleep disturbances.Īs sleep symptoms are commonly elicited by targeted questioning of patients and bed-partners, it is easy to appreciate why sleep dysfunction may be overlooked in patients presenting with prominent cognitive changes, movement disorders, seizures, and other sequelae of a neuroinflammatory process. Increased screening for AE has improved recognition of affected patients, with revised estimates of incidence and prevalence suggesting that AE may be as common as infectious encephalitis in developed countries. Early identification of affected patients is important, as early induction of first-line immunotherapies (i.e., high-dose methylprednisolone and intravenous immunoglobulin) is associated with better long-term outcomes. Although clinical findings are typically accompanied by cerebrospinal fluid (CSF) pleocytosis and characteristic findings on magnetic resonance imaging (MRI), cases without objective markers of inflammation are increasingly recognized in clinical practice. These provides evidence for prevention and treatment of sub-health with TCM.Autoimmune encephalitis (AE) is an inflammatory brain disorder characterized by the subacute onset of psychiatric symptoms, cognitive impairment, and focal neurologic deficits or seizures. ![]() The commonest syndromes of sub-healthy people are insufficiency of Pi-qi type, Gan qi stagnation and Pi deficiency type, deficiency of Xin and Pi type, retention of dampness due to Pi deficiency type, qi deficiency type. The commonest risk factors are lack of relaxation and physical exercise, working with frequent shift, air and noise pollution. The commonest symptoms in sub-healthy people are fatigue, poor quality of sleep, amnesia, irrelievable fatigue after taking rest, dry throat, dizziness, dry and xeritic eyes, ache with distension in eyes, ache, early awakening, difficulty in falling asleep, irritability, etc. The commonest syndrome types in sub-healthy people were insufficiency of Pi-qi type 10.2%, Gan-qi stagnation and Pi deficiency type 10.1%, deficiency of Xin and Pi type 9.7 %, retention of dampness due to Pi-deficiency type 7.4% and qi deficiency type 4.2%, et al. The commonest risk factors were lack of relaxation 60.4%, lack of physical exercise 58.0%, working with frequent extra shifts 56.7%, air pollution 56.2%, noise pollution 51.3%, etc. The commonest symptoms and their frequency in sub-healthy people were fatigue 78.7%, poor quality of sleep 73.4%, amnesia 59.9%, fatigue irrelievable after rest 59.1%, dry throat 59.0%, dizziness 58.6%, dry and xerotic eyes 58.3%, ache with distension eyes 57.8%, ache 56.4%, early awakening 52.7%, difficulty in falling asleep 52.5%, irritability 51.8%, etc. Questionnaire of clinical epidemiological investigation was adopted in the sub-healthy people. To study the common characters of sub-healthy people. ![]()
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